Clinical Scenario
A 52-year-old man with diabetic neuropathic pain has read on the Internet that some seizure medicines are helpful, and he asks for your recommendation.
Clinical Question
How effective is carbamazepine (Tegretol) in controlling pain?
Evidence-Based Answer
Two small trials have shown carbamazepine to be beneficial in the treatment of d…
Temporal lobe seizure is the most frequent cause of partial seizures and aura. During a temporal lobe seizure, you may smack your lips, swallow repeatedly or pick at things with your fingers. Such activities are called automatisms. The temporal lobe is located close to the ear. Temporal lobe seizures can affect people of any age, and can occur as a single episode or can be repeated as part of a chr…
April 30, 2008 — Young women
taking the commonepilepsy drug Dilantin may risk bone loss and fracture with
long-term use.
A new study shows young women taking phenytoin (also commonly known as
Dilantin) for one year lost 2.6% of the bone density in the femoral neck — the
upper part of the thigh bone nea…
Key Dynamics Shaping Market:
* Drug treatment costs decline in major therapy areas
* Shift in growth from top seven markets to emerging markets, and from primary care to specialty care
* Increased uncertainty over safety, pricing and market access, and intellectual property issues
NORWALK, Conn….
An estimated 0.5%-2% of pregnant women are on antiepileptic medication. Most experts would agree that medical treatment of seizures cannot be stopped during pregnancy because of the high risks to the fetus if the mother has a seizure. The problem is that most first-line antiepileptic drugs have been associated with some degree of fetal risk, although the vast majority of exposed fetuses are not affected.
Some studies suggest epilepsy itself is associated with a higher risk of …
Cohrane Abstract
Content not available due to copyright restrictions.
Clinical Scenario
A 70-year-old woman with poorly controlled type 2 diabetes presents with burning, bilateral pain in her legs that is worsening; she requests medication to relieve he…
MERCK PUT Fosamax (alendronate sodium) and its $3 billion in total 2007 sales in its rear-view mirror last month, following the lapse of patent protection on the osteoporosis drug.
Merck forecast that 2008 sales will decline by at least half that, followed by more attrition later. Fosamax is part of about $20 billion worth of drugs expected to lose patent pr…
